Indian scientists helped rewrite a 50-Year-Old biological rule

Key Points

1. Study published in PNAS overturns 50-year-old model of bacterial gene regulation.
2. Researchers from Bose Institute and Rutgers University found that the sigma cycle is not universal.
3. In Bacillus subtilis, σA factor remains bound to RNA polymerase throughout transcription.
4. Modern techniques like biochemical assays, chromatin immunoprecipitation, and fluorescence-based imaging were used.
5. The discovery has implications for microbiology and the development of antibiotics.